The Journal of laboratory and clinical medicine (1915) (14593902589)

Identifier: journaloflaborat01cent (find matches)

Title: The Journal of laboratory and clinical medicine

Year: 1915 (1910s)

Authors: Central Society for Clinical Research (U.S.)

Subjects: Biological Assay Diagnosis, Laboratory Disease Medicine Medicine Research

Publisher: St. Louis, C. V. Mosby

Contributing Library: Gerstein - University of Toronto

Digitizing Sponsor: University of Toronto

Text Appearing Before Image:

° C. with decomposition. It gives on analysis the fol-lowing percentage composition. 0.1096 gms. give 26.2 c.c. N. at 24° C. and 750.7 mm.0.1288 gms. give 30.2 c.c. N. at 22.5^ C. and 751.3 mm.0.1731 gms. give 0.2827 gms. CO, and 0.063 gms. HoO.0.1345 gms. give 0.0520 gms. H.,0 and 0.2184 gms. CO,. Found Calculated for (QH,3Ne)3 (C,oH3N,0,)326.3144.973.75 The substance agrees in composition with the picrolonate of trimethyl-melamine which is the polymer of methylcyanamide. The polymer was pre-pared from the synthetic methylcyanamide and found to agree in reaction with A B N 26.6 26.28 C 44.54 44.28 H 4.07 4.32 RECORD C. (See opposite page.) (Dog 2)Injection given by femoral vein.Quantityâ5 c.c. 0.4 mgms. of synthetic substance per kilo body weight. Fall in pressure from injection 3 about 25 mm. Hg. Fall in pressure from injection 4 about 0 mm. Hg. Fall in pressure from injection 5 about 0 mm. Hg. Heart rate before injecting 108 per minute. Heart rate after injecting 108 per minute.

Text Appearing After Image:

310 The Journal of Laboratory and Clinical Medicine the natural substance. The picrolonate of the synthetic polymer was found tomelt at 229.4° C. which, is slightly below the melting point of the natural salt.This discrepancy can be explained by the presence of small quantities of methyl-guanidin in the synthetic preparation which owing to the similarity in solubilityof the two picrolonates, could not be completely removed by fractional recrys-tallization. It was found that methylcyanamide polymerizes after a few daysstanding or several evaporations of its watery solution. Therefore the polymershould be expected in the urine from which the cyanamide was isolated. Because of the agreement in chemical and physiological properties (dis-cussed below) the substances may be considered identified as methylcyanamideand trimethylmelamine. Physiological Properties. The methylcvanamide isolated from the urines and the synthetic methyl-cyanamide were injected intraperitoneally in non-anesthetize

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1915

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