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Micromotor nanotoxoids are fabricated in a sequential

description

Summary

Micromotor nanotoxoids are fabricated in a sequential process (a). When micromotor toxoids are administered orally to mice (b), the enteric coating protects the formulation from degradation in the low gastric pH. Then, the enteric coating dissolves in the neutral pH of the intestine, and the intestinal fluid activates the micromotors. The autonomous propulsion facilitates enhanced retention, promoting immunity.

Source: Wei X, Beltrán-Gastélum M, Karshalev E, et al. 2019. Biomimetic micromotor enables active delivery of antigens for oral vaccination. Nano Lett. 19(3):1914–1921. doi: 10.1021/acs.nanolett.8b05051.

Image courtesy of Dr. Liangfang Zhang.

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vaccine mice university of california san diego ucsd nanoparticles micromotor nanotoxoids oral vaccine delivery intestinal wall mucosal wall immunoglobulin a iga small animal study staphylococcus aureus defense threat reduction agency s chemical and biological technologies department fort belvoir va schematic of micromotor toxoids for oral vaccination dvids california
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2000 - 2022
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Defense Visual Information Distribution Service
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https://www.dvidshub.net/
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Public Domain Dedication. Public Use Notice of Limitations: https://www.dvidshub.net/about/copyright

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Topics

vaccine mice university of california san diego ucsd nanoparticles micromotor nanotoxoids oral vaccine delivery intestinal wall mucosal wall immunoglobulin a iga small animal study staphylococcus aureus defense threat reduction agency s chemical and biological technologies department fort belvoir va schematic of micromotor toxoids for oral vaccination dvids california